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Diazepam is normally used for treating insomnia, anxiety, seizures, restless leg syndrome, alcohol withdrawal and Meniere’s disease. It has anxiolytic, hypnotic, skeletal muscle relaxant and amnestic properties. It is sometimes used to reduce tension and anxiety in some surgical procedures.
World Health Organization considered this drug as one of the essential drugs. It has been used with the wide range of conditions and one of the most frequently prescribed medications for the past 40 years. It was Dr. Leo Sternbach who first synthesized this drug and it was Hoffman-La Roche who first marked this drug.
Normally, Valium is prescribed in healthy adults ranging from 2 mg per dose to 10 mg per dose which will be taken 2-4 times a day, depending on individual’s body weight and condition being treated. For elderly users with hepatic disorders, the intial dose is a very low rate and wil be increased as needed.
Valium can be administered orally and parenterally. For oral administration, tablet forms, capsules and liquid solution is available. In tables, 2 mg, 5 mg and 10 mg is readily available. In capsule form, 15 mg is available. In liquid solution, 1 mg/ml in 500 ml containers, and 5 mg/ml in a 30 ml dropper bottle.
For Parenteral administration, IV and Im injections are available. It has 5 mg/ml, 2 ml ampules and synringes, 1 ml, 2 ml, 10 ml vials and 2 ml Tel-E-Ject. However, IM is less effective because this drug does not allow to reach the circulation rapidly.
The mode of action of this drug is that it binds to a specific subunit of the GABA receptor. This receptor is an inhibitory channel that decreases neuronal activity. This acts on the limbic system, hypothalamus and thalamus. The inhibitory of the polysynaptic pathways of the spinal cord results to the muscle relaxant properties of Valium.